Immunofluorescence Detection of Radiation-Induced DNA Base Damage

Radiation - induced base damage – FPG - sensitive sites in plasmid DNA

Major progress of the Heidelberg ion beam cancer ther-apy centre took place in 2007. The first turn of the beamin the synchrotron was reached on February, 7th. Firstbeam in a treatment room was achieved on March, 20th.Until December, 16ththe beam performance in the firsttwo treatment rooms was pushed to the quality which isrequired for patient tre...

Radiation-induced base damage – FPG-sensitive sites in plasmid DNA

Radiation-induced damage in DNA depends on the pattern of deposited energy – homogeneous in case of X-rays and very inhomogeneous for charged particles (energy deposited along their tracks in a correlated way). It is accepted that the biological effect, its complexity and severity, induced by lowand high-LET radiation (X-rays and charged particles, respectively) is strongly dependent on the dis...

Radiation track and DNA damage

Radiation-induced DNA damage responses.

The amazing feature of ionising radiation (IR) as a DNA damaging agent is the range of lesions it induces. Such lesions include base damage, single strand breaks (SSBs), double strand breaks (DSBs) of varying complexity and DNA cross links. A range of DNA damage response mechanisms operate to help maintain genomic stability in the face of such damage. Such mechanisms include pathways of DNA rep...

radiation track and dna damage

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